|
Liver diseases
|
0.360 |
GeneticVariation
|
group |
BEFREE |
We hereby report the association of liver disease with homozygous mutations in the conserved ATP hinge region of exon 18 of the ATP7B gene.
|
20485189 |
2010 |
|
Liver diseases
|
0.360 |
Biomarker
|
group |
BEFREE |
Decreased biliary copper excretion and reduced incorporation of copper into apoceruloplasmin caused by defunctionalization of ATP7B protein lead to accumulation of copper in many tissues and organs, including liver, brain, and cornea, finally resulting in liver disease and extrapyramidal symptoms.
|
26112727 |
2015 |
|
Liver diseases
|
0.360 |
Biomarker
|
group |
CTD_human |
In this cell-free system, copper induced thiol modifications of three abundant mitochondrial membrane proteins, and this correlated with reversible intramitochondrial membrane crosslinking, which was also observed in liver mitochondria from Atp7b–/– rats.
|
21364284 |
2011 |
|
Liver diseases
|
0.360 |
GeneticVariation
|
group |
BEFREE |
Wilson's disease is an autosomal recessive disorder characterized by liver disease and/or neurologic deficits due to copper accumulation and is caused by pathogenic mutations in the ATP7B gene.
|
28856630 |
2017 |
|
Liver diseases
|
0.360 |
Biomarker
|
group |
BEFREE |
Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B(-/-) (Wilson disease) mice.
|
26679751 |
2016 |
|
Liver diseases
|
0.360 |
Biomarker
|
group |
BEFREE |
Four rodent models with ATP7B gene defects have been described - the Long-Evans Cinnamon (LEC) rat, inbred mouse models (toxic milk (tx), the Jackson Laboratory toxic milk (tx-j)), and the genetically engineered ATP7B<sup>-/-</sup> (knockout) mouse - all of which develop liver disease to different extents.
|
28433110 |
2017 |
|
Liver diseases
|
0.360 |
Biomarker
|
group |
BEFREE |
The ATP7B-classical form with hypoceruloplasminemia has primary hepatopathy and late extra-hepatic complications, while the severe hepatic form is free from ATP7B mutation and hypoceruloplasminemia, and silently progresses to liver failure.
|
29882374 |
2018 |
|
Liver neoplasms
|
0.340 |
Biomarker
|
group |
CTD_human |
Incidences of spontaneous liver tumors in LEC, WKAH.C-Atp7b and WKAH rats correlated with hepatic copper and iron concentrations.
|
11509115 |
2001 |
|
Liver neoplasms
|
0.340 |
Biomarker
|
group |
BEFREE |
The aim of this study was to clarify the mechanism underlying ATP7B-mediated copper detoxification by investigating endogenous ATP7B localization in the HepG2 hepatoma cell line and its ability to mediate vesicular sequestration of excess intracellular copper.
|
16472602 |
2006 |
|
Liver neoplasms
|
0.340 |
GeneticVariation
|
group |
BEFREE |
Defective cellular localization of mutant ATP7B in Wilson's disease patients and hepatoma cell lines.
|
12557139 |
2003 |
|
Liver neoplasms
|
0.340 |
Biomarker
|
group |
BEFREE |
Copper-resistant hepatoma HepG2 cell lines lacking ATP7B were generated.
|
28805879 |
2017 |
|
Liver neoplasms
|
0.340 |
Biomarker
|
group |
BEFREE |
The effect of zinc and D-penicillamine in a stable human hepatoma ATP7B knockout cell line.
|
24892424 |
2014 |
|
Carcinoma
|
0.320 |
Biomarker
|
group |
CTD_human |
Copper-transporting P-type adenosine triphosphatase (ATP7B) is expressed in human breast carcinoma.
|
11802810 |
2002 |
|
Carcinoma
|
0.320 |
Biomarker
|
group |
BEFREE |
These results indicate that the analysis of the ATP7B gene and/or protein will be helpful for the choice of chemotherapy in patients with human solid carcinomas.
|
12820478 |
2003 |
|
Carcinoma
|
0.320 |
Biomarker
|
group |
CTD_human |
Copper-transporting P-type adenosine triphosphatase (ATP7B) as a cisplatin based chemoresistance marker in ovarian carcinoma: comparative analysis with expression of MDR1, MRP1, MRP2, LRP and BCRP.
|
12216079 |
2002 |
|
Carcinoma
|
0.320 |
Biomarker
|
group |
BEFREE |
Copper-transporting P-type adenosine triphosphatase (ATP7B) is reportedly associated with platinum drug resistance in various solid carcinomas.
|
18636185 |
2008 |
|
Colorectal Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
In conclusion, ATP7B mRNA and protein expression in colorectal tumors is associated with clinical outcome to oxaliplatin/5FU.
|
19296535 |
2009 |
|
Colorectal Neoplasms
|
0.310 |
AlteredExpression
|
group |
BEFREE |
In conclusion, ATP7B mRNA and protein expression in colorectal tumors is associated with clinical outcome to oxaliplatin/5FU.
|
19296535 |
2009 |
|
Hepatitis
|
0.310 |
Biomarker
|
group |
CTD_human |
Gene expression in the liver of Long-Evans cinnamon rats during the development of hepatitis.
|
14574444 |
2003 |
|
Hepatitis
|
0.310 |
Biomarker
|
group |
CTD_human |
Dietary polyunsaturated fatty acids suppress acute hepatitis, alter gene expression and prolong survival of female Long-Evans Cinnamon rats, a model of Wilson disease.
|
15135151 |
2004 |
|
Hepatitis
|
0.310 |
GeneticVariation
|
group |
LHGDN |
Early and severe liver disease associated with homozygosity for an exon 7 mutation, G691R, in Wilson's disease.
|
17718866 |
2007 |
|
Mouth Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) as a chemoresistance marker in human oral squamous cell carcinoma treated with cisplatin.
|
12509969 |
2003 |
|
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Copper signaling axis as a target for prostate cancer therapeutics.
|
25320179 |
2014 |
|
Malignant neoplasm of mouth
|
0.300 |
Biomarker
|
group |
CTD_human |
Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) as a chemoresistance marker in human oral squamous cell carcinoma treated with cisplatin.
|
12509969 |
2003 |
|
Dyslipidemias
|
0.300 |
Biomarker
|
group |
CTD_human |
Abnormal hepatobiliary and circulating lipid metabolism in the Long-Evans Cinnamon rat model of Wilson's disease.
|
17303181 |
2007 |